Cosmoperine is mixed with our naturally-derived sleep formula on the Sleep ZPatch. It's prepared from piperine (found in black pepper and long pepper) by a patented proprietary process. Cosmoperine used to increase the absorption of drugs and nutrients through the skin.
There are no reported cases of sleep enhancement with cosmoperine, the compound is merely used to increase skin absorption of other compounds.
How It Works
The mechanism of action is currently unclear but possible explanations include increasing cell membrane fluidity allowing compounds to pass through or making the compound more likely to attach the cell membrane which would facilitate passage into the cell.
Dosing and Administration
Cosmoperine can be used in a patch to facilitate absorption through skin. No toxicity reports have been noted with doses at or below 50mg/kg bodyweight.
In a small study (46 people) there were no side effects reported.
when used in a patch to facilitate absorption there does not appear to be any safety risks at this time. Consult with your doctor if having any issues while using cosmoperine.
2 Badmaev, V; Majeed, M; Skin and Its Role In Providing Nourishment To the Body – Pungent Principles of Black Pepper, Alkaloid Piperine, and Tetrahydropiperine (THP) as Enhancers of Nutrient and Drug Bioavailability. Cosemtic Science Technology 2004.